Citation

Harrison MB, Wiley RG, Wooten GF. Brain Res. 1992; 590(1-2): 305-310.

Copyright

(Copyright © 1992, International Brain Research Organization, Publisher Elsevier Publishing)

DOI

10.1016/0006-8993(92)91111-q

PMID

1422839

Abstract

We have used the immunotoxin OX7/saporin, a suicide transport agent, to selectively lesion striatopallidal neurons. Following injection of OX7/saporin into the globus pallidus, in situ hybridization for preproenkephalin mRNA was examined in the striatum to confirm successful retrograde neurotoxicity. Comparison of D1 and D2 receptor binding in the striatum demonstrated that D2 but not D1 receptor binding sites are localized to striatopallidal neurons.

Language: en

Keywords

Animals; Corpus Striatum; Globus Pallidus; Immunotoxins; In Situ Hybridization; Male; N-Glycosyl Hydrolases; Neurons; Plant Proteins; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Ribosome Inactivating Proteins, Type 1; Saporins