Citation

Arranz B, Blennow K, Ekman R, Eriksson A, Marcusson J. Hum. Psychopharmacol. 1996; 11(6): 451-461.

Copyright

(Copyright © 1996, John Wiley and Sons)

DOI

10.1002/(sici)1099-1077(199611)11:6<451::aid-hup812>3.0.co;2-%23

PMID

unavailable

Abstract

To examine how neuropeptide dysfunction may account for some of the behavioural and physiological alterations observed in depressive illness, neuropeptide Y (NPY), somatostatin (SOM) and corticotropin-releasing factor (CRF)-like immunoreactivity (LI), was measured in frontal cortex, gyrus cinguli and hypothalamus from 18 suicide victims and 23 matched controls. A high performance liquid chromatography separation of the NPY immunoreactive fragments was also performed. Overall suicides did not show significant differences with respect to the control group. However, a significant increase in NPY-LI was noted in the frontal cortex of those suicides dying from carbon monoxide poisoning. The chromatographic characterization showed a distinctly different NPY-LI peak pattern in the depressed suicides, which suggests the possibility of depression being associated with an alteration in the catabolic products of certain neuropeptidergic systems.

Language: en

Keywords

adult; human; suicide; female; male; brain; depression; intoxication; article; controlled study; behavior; clinical article; priority journal; carbon monoxide; corticotropin releasing factor; neuropeptide; somatostatin; neuropeptide Y; human brain; corticotropin-releasing factor