Citation

Husain K, Sahu RN, Rahman R, Nair A. Indian J. Clin. Biochem. 1995; 10(1): 45-47.

Copyright

(Copyright © 1995, Association of Clinical Biochemists, Publisher Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/BF02873669

PMID

unavailable

Abstract

The levels of norepinephrine (NE), dopamine (DA) serotonin (5-HT) and its metabolite 5-hydroxyindole acetic acid (5-HIAA) have been determined in the cerebrospinal fluid (CSF) of normal (n=25) and suicidal attempt cases (n=30). A significant decrease in the level of NE (p<0.01), 5-HT(p<0.001) and 5-HIAA (p<0.001) in the CSF of suicide attempt cases were observed as compared to normal controls. It is concluded that CSF 5-HIAA level which is drastically depleted may be used as an early biochemical indicator of suicidal attempt so that it may be treated by the drugs which can enhance the suppressed neurotransmitter activity. © 1995 Association of Clinical Biochemists of India.

Language: en

Keywords

adult; human; Suicide; female; male; suicide attempt; clinical trial; Dopamine; serotonin; Serotonin; article; controlled study; clinical article; controlled clinical trial; 5 hydroxyindoleacetic acid; noradrenalin; dopamine; 5-HIAA; biochemical marker; Norepinephrine; cerebrospinal fluid level; biogenic amine