Citation

Tsuchihashi H, Nishikawa M. Japanese Journal of Forensic Toxicology 1995; 13(1): 1-10.

Copyright

(Copyright © 1995)

DOI

unavailable

PMID

unavailable

Abstract

Quaternary ammonium drugs, muscular relaxants suxamethonium and pancuronium, are sometimes examined in forensic laboratories in the cases of suicide or homicide. It is difficult to extract these drugs from biological samples using organic solvents, because of their water solubility. These drugs are not volatile so that their gas chromatographic (GC) and gas chromatographic/mass spectrometric (GC/MS) analyses are difficult in their underivatized forms. In this paper, we have reviewed analyses for quaternary ammonium drugs by GC, HPLC and GC/MS.

Language: ja

Keywords

human; review; high performance liquid chromatography; mass spectrometry; gas chromatography; suxamethonium; pancuronium; analytical toxicology; biomaterial; quaternary ammonium derivative; quaternary ammonium drugs