Citation

Misaki M, Ueyama Y, Morita O, Matsumura T. Journal of Japan Society for Cancer Therapy 1995; 30(1): 9-16.

Copyright

(Copyright © 1995)

DOI

unavailable

PMID

unavailable

Abstract

We evaluated the effects of rhG-CSF daily administration (1 day, 2 days, 3 days administration) on neutrophil counts in peripheral blood and expansion of granulocyte progenitor cells in bone marrow in mice. 1. As the beginning of rhG-CSF administration, neutrophil counts gradually rose and returned to starting level soon after discontinuation of rhG-CSF. On the other hand, granulocyte progenitor cell counts reached highest peak after 1 day of rhG-CSF administration and did not rise as rhG-CSF administration continued and subsequently, returned to starting level. 2. The percentage of the S-phase granulocyte progenitor cells (suicide rate) rose as rhG-CSF administration continued, showing proliferating effect of rhG-CSF on granulocyte progenitor cells in 2 days and 3 days administration groups. Subsequently, it began to decline remarkably after 2 days of discontinuation of rhG-CSF. These findings suggested that patterns of the response of granulocyte progenitor cell counts and S-phase granulocyte progenitor cell counts to rhG-CSF administration, especially after discontinuation of rhG-CSF, were quite different from those of neutrophil counts. It seemed to be necessary that not only neutrophil counts but also expansion of granulocyte progenitor cells should be taken into consideration when evaluating the effect of rhG-CSF administration.

Language: ja

Keywords

article; cell proliferation; nonhuman; mouse; drug effect; animal experiment; animal; blood cell count; stem cell; neutrophil; G-CSF; granulocyte precursor; granulocyte progenitor cell; recombinant granulocyte colony stimulating factor