Citation

Elia D, Koscielny S, Le M, Chaby L, Colnat P, Dergelet L, Grinsztein A, Hamon J, Pichard C. Reproduction Humaine et Hormones 1994; 7(6): 255-258+261.

Copyright

(Copyright © 1994)

DOI

unavailable

PMID

unavailable

Abstract

Depression frequency among postmenopausal women have been variably reported by authors. This study tried to specify the components prevalence of these psychological symptoms and their variations after hormone replacement therapy. We tried too to find any relations between the symptoms, between Serotonin, Epinephrin, Norepinephrin, Histamine and Dopamine, between the symptoms and these monoamines before and after treatment. Mean HARD score before treatment was found to be 22, 39 which correspond to low depression ('anxio-slow' type). 5 items were significantly improved after treatment: lassitude, sadness, anxiety, concentration deficiency. Estradiol increase was clearly correlated to the HARD's A component decrease (anxiety and insomnia). Significative relationship (positive between Serotonine and Sadness) (negative between Histamine and Anxiety, concentration deficiency), (negative between Dopamine and Suicide ideas), have been noticed. But the treatment did not induce significant cathecholamines variations.

Language: fr

Keywords

adult; human; female; insomnia; depression; anxiety; clinical trial; serotonin; article; major clinical study; controlled study; controlled clinical trial; noradrenalin; dopamine; histamine; gestagen; adrenalin; estrogen; hormone substitution; postmenopause; estrogens; HARD; monoamines