Citation

Shin KH, Woo WS, Moon KH, Yoo SJ. Arch. Pharm. Res. 1993; 16(1): 13-17.

Copyright

(Copyright © 1993, Pharmaceutical Society of Korea, Publisher Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/BF02974121

PMID

unavailable

Abstract

Several naturally occurring furanocoumarins significantly inhibited microsomal lipid peroxidation not only mediated by endogeneous iron and NADPH but also initiated by CCl4 metabolites. Phellopterin, a potent inhibitor of cytochrome P-450, exhibited an almost complete inhibition of CCl4-induced hepatotoxicity as measured by sGPT activity 24 hr after CCl4 intoxication, whereas other furanocoumarins such as imperatorin, byakangelicin and oxypeucedanin methanolate exerted no protective effect. When compared with other cytochrome P-450 inhibitors (SKF-525A, AIA) and silymarin given at the same dose level (ED50), phellopterin still showed a significant inhibition of hepatotoxicity which was even stronger than that of AIA, known as a typical suicide inhibitor. Phellopterin was partially effective when given 30 min after CCl4 treatment. Repeated administrations of phellopterin, however resulted in a complete loss of the protection against CCl4-induced hepatotoxicity. © 1993, The Pharmaceutical Society of Korea. All rights reserved.

Language: en

Keywords

male; article; controlled study; unclassified drug; nonhuman; mouse; animal experiment; liver toxicity; rat; lipid peroxidation; coumarin derivative; silymarin; carbon tetrachloride; CCl4-induced hepatotoxicity; intraperitoneal drug administration; Lipid peroxidation; Naturally occurring furanocoumarins; phellopterin; Phellopterin; proadifen; protective agent; sGPT