Citation

Zumwalt JG, Neal JJ. Comp. Biochem. Physiol. C 1993; 106(1): 111-118.

Copyright

(Copyright © 1993, http://www.sciencedirect.com/science/journal/03064492, Publisher Elsevier Publishing)

DOI

10.1016/0742-8413(93)90261-I

PMID

unavailable

Abstract

1. Papilio polyxenes, a caterpillar which feeds on xanthotoxin-containing plants, has cytochromes P450 that are six- to 100-fold less sensitive to the suicide substrate inhibitor, xanthotoxin, than cytochromes P450 from Manduca sexta, which does not survive on xanthotoxin-containing plants. 2. Xanthotoxin is a suicide substrate inhibitor of O-demethylation of p-nitroanisole by M. sexta microsomes but a reversible inhibitor of O-demethylation by P. polyxenes microsomes. 3. Aldrin epoxidation is irreversibly inhibited by xanthotoxin in both species. 4. Patterns of cross inhibition demonstrate that O-demethylase and aldrin epoxidase from both species and the P. polyxenes xanthotoxin-metabolizing cytochrome P450 are distinct enzymes. © 1993.

Language: en

Keywords

article; priority journal; plant; concentration response; methoxsalen; feeding; insect; radioisotope; species difference; cytochrome p450; 4 nitroanisole; aldrin; aldrin epoxidase; demethylation; o demethylase; xenobiotic metabolism