Citation

Dunbar G. Nord. J. Psychiatry 1992; 46(S27): 41-46.

Copyright

(Copyright © 1992, Informa - Taylor and Francis Group)

DOI

10.3109/08039489209101160

PMID

unavailable

Abstract

The most frequent adverse events associated with paroxetine treatment include nausea (12% somnolence (11% sweating (9% tremor (8% asthenia (7% dry mouth (7% insomnia (6% constipation (4% dizziness (4% reduced libido (3% blurred vision (3% and delayed ejaculation (9% of males). Adverse events are dose related and occur early in therapy. Such adverse events are usually mild, well tolerated, and only occasionally lead to dropout. Paroxetine does not interact with alcohol, and other drug-drug interactions are unlikely with most commonly prescribed medications. The few exceptions include the monoamine oxidase inhibitors (MAOIs), tryptophan, procyclidine, warfarin, and hepatic enzyme inhibitors/inducers. Seizures are less frequent in patients on paroxetine than in those receiving tricyclic antidepressants. Also, paroxetine is less likely to precipitate mania in bipolar patients. Suicide and suicide attempts are no more frequent on paroxetine than active (tricyclic) control or placebo. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Language: en

Keywords

Safety; human; alcohol; insomnia; suicidal behavior; Tolerability; conference paper; amitriptyline; clomipramine; imipramine; monoamine oxidase inhibitor; paroxetine; xerostomia; somnolence; vertigo; mianserin; procyclidine; seizure; tremor; benzodiazepine; sweating; mania; side effect; asthenia; phenytoin; warfarin; anticholinergic effect; ejaculation; Paroxetine; tryptophan; adverse drug reaction