Citation

Sanaa S. S, Ibrahim A. R. Egypt. J. Psychiatr. 1992; 15(1): 53-65.

Copyright

(Copyright © 1992, Egyptian National Scientific Technical Information Network ( ENSTINET ), Publisher Wolters Kluwer/Medknow Publications)

DOI

unavailable

PMID

unavailable

Abstract

This study evaluates the potential antidote action of naloxone on experimentally induced diazepam and flunitrazepam [benzodiazepines] intoxication in dogs. Its antidote effects is also evaluated in a clinical sample of 8 patients suffering from flunitrazepam intoxication. The clinical findings were suggestive of an antagonistic action of naloxone in flunitrazepam intoxication. It was also found that flunitrazepam exhibits a different pharmacological profile from other members of the benzodiazepine group. Our findings of a selective naloxane-flunitrazepam reversal need to be explained in relation to the mechanism of action of this benzodiazepine, as well as to the equated naloxane-opiates reversal

Language: en