Citation

Emens JS, Berman AM, Thosar SS, Butler MP, Roberts SA, Clemons NA, Herzig MX, McHill AW, Morimoto M, Bowles NP, Shea SA. Psychiatry Res. 2020; 293: e113337.

Copyright

(Copyright © 2020, Elsevier Publishing)

DOI

10.1016/j.psychres.2020.113337

PMID

32777620

PMCID

PMC8053038

Abstract

In humans, there is an endogenous, near 24-h (i.e., circadian) variation in mood with the best mood occurring during the circadian day and the worst mood occurring during the circadian night. Only positive affect, and not negative affect, has been shown to contribute to this circadian rhythm. We discovered a sharp circadian peak in negative affect during the circadian night coincident with a circadian trough in positive affect. These findings may help explain the association of depression with insomnia, the increased risk of suicide with nocturnal wakefulness, and the correlation between circadian misalignment and symptom severity in Major Depressive Disorder.

Language: en

Keywords

Actigraphy; Affect; Circadian; Circadian Rhythm; Female; Humans; Male; Middle Aged; Mood disorders; Mood Disorders; Sleep; Sleep Disorders, Circadian Rhythm; Wakefulness