Citation

Mazza MG, De Lorenzo R, Conte C, Poletti S, Vai B, Bollettini I, Melloni EMT, Furlan R, Ciceri F, Rovere-Querini P, COVID-19 BioB Outpatient Clinic Study group, Benedetti F. Brain Behav. Immun. 2020; 89: 594-600.

Copyright

(Copyright © 2020, Elsevier Publishing)

DOI

10.1016/j.bbi.2020.07.037

PMID

32738287

PMCID

PMC7390748

Abstract

Infection-triggered perturbation of the immune system could induce psychopathology, and psychiatric sequelae were observed after previous coronavirus outbreaks. The spreading of the Severe Acute Respiratory Syndrome Coronavirus (COVID-19) pandemic could be associated with psychiatric implications. We investigated the psychopathological impact of COVID-19 in survivors, also considering the effect of clinical and inflammatory predictors. We screened for psychiatric symptoms 402 adults surviving COVID-19 (265 male, mean age 58), at one month follow-up after hospital treatment. A clinical interview and a battery of self-report questionnaires were used to investigate post-traumatic stress disorder (PTSD), depression, anxiety, insomnia, and obsessive-compulsive (OC) symptomatology. We collected sociodemographic information, clinical data, baseline inflammatory markers and follow-up oxygen saturation levels. A significant proportion of patients self-rated in the psychopathological range: 28% for PTSD, 31% for depression, 42% for anxiety, 20% for OC symptoms, and 40% for insomnia. Overall, 56% scored in the pathological range in at least one clinical dimension. Despite significantly lower levels of baseline inflammatory markers, females suffered more for both anxiety and depression. Patients with a positive previous psychiatric diagnosis showed increased scores on most psychopathological measures, with similar baseline inflammation. Baseline systemic immune-inflammation index (SII), which reflects the immune response and systemic inflammation based on peripheral lymphocyte, neutrophil, and platelet counts, positively associated with scores of depression and anxiety at follow-up. PTSD, major depression, and anxiety, are all high-burden non-communicable conditions associated with years of life lived with disability. Considering the alarming impact of COVID-19 infection on mental health, the current insights on inflammation in psychiatry, and the present observation of worse inflammation leading to worse depression, we recommend to assess psychopathology of COVID-19 survivors and to deepen research on inflammatory biomarkers, in order to diagnose and treat emergent psychiatric conditions.

Language: en

Keywords

Adolescent; Adult; Aged; Aged, 80 and over; Anxiety; Anxiety Disorders; Betacoronavirus; C-Reactive Protein; Coronavirus Infections; COVID-19; COVID-19 survivors; Depression; Depressive Disorder; Depressive Disorder, Major; Emergency Service, Hospital; Female; Humans; Inflammation; Insomnia; Italy; Length of Stay; Leukocyte Count; Lymphocyte Count; Male; Mental Disorders; Mental health; Middle Aged; Monocytes; Neutrophils; Obsessive-compulsive disorder; Obsessive-Compulsive Disorder; Pandemics; Pneumonia, Viral; Psychopathology; PTSD; SARS-CoV-2; Severity of Illness Index; Sex Factors; Sleep Initiation and Maintenance Disorders; Stress Disorders, Post-Traumatic; Suicidal Ideation; Survivors; Young Adult