Citation

Gallay CC, Forsyth G, Can AT, Dutton M, Jamieson D, Jensen E, Hermens DF, Bennett MR, Lagopoulos J. Psychiatry Res. Neuroimaging 2021; 317: e111369.

Copyright

(Copyright © 2021, Elsevier Publishing)

DOI

10.1016/j.pscychresns.2021.111369

PMID

34461430

Abstract

Chronic suicidality has been associated with neuronal atrophy in cortico-striato-limbic regions and is thought to be mediated via a glutamatergic imbalance. Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has been posited to exert anti-suicidal effects by promoting neurogenesis via modulation of glutamatergic transmission. This voxel-based morphometry study examined the effect of ketamine on whole brain grey matter in adults with chronic suicidality. Grey matter in the periaqueductal grey, nucleus accumbens, putamen, caudate, and thalamus was significantly increased following 6 weeks of low dose oral ketamine treatment. These results support the notion that ketamine rapidly enhances synaptic plasticity within striato-limbic regions.

Language: en

Keywords

Humans; Adult; Depression; Suicide; Suicidal Ideation; Ketamine; Glutamate; Gray Matter; Magnetic resonance imaging (MRI); Receptors, N-Methyl-D-Aspartate