Citation

Mohutsky M, Hall SD. Methods Mol. Biol. 2021; 2342: 51-88.

Copyright

(Copyright © 2021, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/978-1-0716-1554-6_3

PMID

34272691

Abstract

This chapter describes the types of irreversible inhibition of drug-metabolizing enzymes and the methods commonly employed to quantify the irreversible inhibition and subsequently predict the extent and time course of clinically important drug-drug interactions.

Language: en

Keywords

Humans; Time Factors; Drug Interactions; Pharmaceutical Preparations; Kinetics; Suicide inhibition; Catalysis; Cytochrome P-450 Enzyme System; Inhibitory Concentration 50; Cytochrome P-450 Enzyme Inhibitors; Xenobiotics; Drug–drug interaction; Enzyme inactivation; Heme; IC50 shift; Mechanism-based inhibition; Metabolite intermediate complex; Time-dependent inhibition