Citation

Ejikeme C, Elkattawy S, Kayode-Ajala F, Abuaita S, Khazai M. Cureus 2021; 13(5): e15085.

Copyright

(Copyright © 2021, Curēus)

DOI

10.7759/cureus.15085

PMID

34155455

PMCID

PMC8209760

Abstract

Oxcarbazepine is a well-known and effective anti-convulsant used for patients with underlying seizure disorder. It is a structural analog of carbamazepine; however, it follows a different metabolic pathway in which it is converted to a different active metabolite. Side effects associated with this medication are vast; however, in this report, we will hone in on the renal adverse effects, e.g., syndrome of inappropriate anti-diuretic hormone secretion (SiADH). SiADH is a condition in which the body is making too much anti-diuretic hormone, which, in turn, results in "too much" water absorption, causing hyponatremia with neurologic sequelae. Our patient is a 31-year-old gentleman with a history of depression, anxiety, bipolar disorder, and previous suicide attempts who presented to the emergency department following oxcarbazepine overdose and was subsequently found to be hyponatremic secondary to having SiADH.

Language: en

Keywords

hyponatremia; anti-convulsant; electrolyte disturbances; oxcarbamazepine; siadh