Citation

Sasaki Y, Tsujii N, Sasaki S, Sunakawa H, Toguchi Y, Tanase S, Saito K, Shinohara R, Kurokouchi T, Sugimoto K, Itagaki K, Yoshida Y, Namekata S, Takahashi M, Harada I, Hakosima Y, Inazaki K, Yoshimura Y, Mizumoto Y, Okada T, Usami M. PLoS One 2021; 16(6): e0252420.

Copyright

(Copyright © 2021, Public Library of Science)

DOI

10.1371/journal.pone.0252420

PMID

34081716

PMCID

PMC8174687

Abstract

BACKGROUND/AIM: Patients with attention-deficit hyperactivity disorder (ADHD) manifest symptoms of hyperactivity, impulsivity, and/or inattention. ADHD medications available in Japan are limited compared with those in Western countries. Prescribing status has not been sufficiently evaluated in clinical settings in Japan. This study investigated the current use of ADHD medications and characteristics of patients who received multiple ADHD medications in a clinical setting in Japan.
METHODS: Study participants were those who visited the Department of Child and Adolescent Psychiatry, Kohnodai Hospital between April 2015 and March 2020. We investigated patients who received osmotic-controlled release oral delivery system methylphenidate, atomoxetine, or guanfacine. A retrospective case-control design was used to evaluate the characteristics of patients who received multiple ADHD medications. Patients who were given three ADHD medications were defined as the case group. Randomly sampled sex- and age-matched patients diagnosed with ADHD were defined as the control group. We compared data for child-to-parent violence, antisocial behavior, suicide attempt or self-harm, abuse history, refusal to attend school, and two psychological rating scales (the ADHD-Rating Scale and Tokyo Autistic Behavior Scale).
RESULTS: Among the 878 patients who were prescribed any ADHD medications, 43 (4.9%) received three ADHD medications. Logistic regression revealed that children with severe ADHD symptoms, autistic characteristics, or tendency of child-to-parent violence were more likely to have been prescribed three medications during their treatment.
CONCLUSIONS: Our findings suggest the approach to prevent the use of multiple ADHD medications. A prospective study to investigate the causality between prescribing status and clinical characteristics is warranted.

Language: en

Keywords

Humans; Child; Female; Logistic Models; Male; Japan; Prospective Studies; Retrospective Studies; Outpatients; Methylphenidate; Attention Deficit Disorder with Hyperactivity; Atomoxetine Hydrochloride; Guanfacine