Citation

Caruso D, Palagini L, Miniati M, Massa L, Marazziti D, Geoffroy PA, Etain B. J. Nerv. Ment. Dis. 2021; 209(7): 518-524.

Copyright

(Copyright © 2021, Lippincott Williams and Wilkins)

DOI

10.1097/NMD.0000000000001333

PMID

34170861

Abstract

The study aimed at investigating the potential impact of early stressful events on the clinical manifestations of bipolar disorder (BD). A sample of 162 adult individuals with BD was assessed using the Structural Clinical Interview for DSM-5, the Beck Depression Inventory-II, the Young Mania Rating Scale, the Early Trauma Inventory Self Report-Short Form, the Biological Rhythms Interview of Assessment in Neuropsychiatry, the Insomnia Severity Index, and the Scale for Suicide Ideation. A significant path coefficient indicated a direct effect of early life stressors on biological rhythms (coeff. = 0.26; p < 0.001) and of biological rhythms on depressive symptoms (coeff. = 0.5; p < 0.001), suicidal risk (coeff. = 0.3; p < 0.001), and insomnia (coeff. = 0.34; p < 0.001). Data suggested that the desynchronization of chronobiological rhythms might be one mediator of the association between early life stress and the severity of mood symptoms/suicidal ideation in BD. Addressing circadian rhythm alterations in subjects exposed to early stressors would help in preventing consequences of those stressors on BD.

Language: en

Keywords

Humans; Cross-Sectional Studies; Adult; Female; Male; Middle Aged; Risk; Depression; Comorbidity; Suicidal Ideation; Italy; Circadian Rhythm; Bipolar Disorder; Depressive Disorder, Major; Sleep Initiation and Maintenance Disorders; Adverse Childhood Experiences; Patient Acuity; Chronobiology Disorders