Citation

Girgis RR, Basavaraju R, France J, Wall MM, Brucato G, Lieberman JA, Provenzano FA. Psychiatry Res. Neuroimaging 2021; 312: e111287.

Copyright

(Copyright © 2021, Elsevier Publishing)

DOI

10.1016/j.pscychresns.2021.111287

PMID

33848727

PMCID

PMC8137659

Abstract

Suicide is a major cause of death in psychosis and associated with significant morbidity. Suicidal ideation (SI) is very common in those at clinical high-risk for psychosis (CHR) and predicts later suicide. Despite substantial work on the pathobiology of suicide in schizophrenia, little is known of its neurobiological underpinnings in the CHR or putatively prodromal state. Therefore, in this pilot study, we examined the neurobiology of SI in CHR individuals using structural MRI. Subjects were aged 14-30 and met criteria for the Attenuated Positive Symptom Psychosis-Risk Syndrome (APSS) delineated in the Structured Interview for Psychosis-Risk Syndromes (SIPS). Suicidality was assessed using the Columbia Suicide Severity Rating Scale (C-SSRS). Volumetric MRI scans were obtained on a 3T Phillips scanner. MRI data were available for 69 individuals (19 CHR without SI, 31 CHR with SI and 19 healthy control subjects). CHR individuals with SI had thicker middle temporal and right insular cortices than CHR individuals without SI and healthy control subjects. The location of these findings is consistent with neurobiological findings regarding suicide in syndromal psychosis. These findings underscore the potential for the use of brain imaging biomarkers of suicide risk in CHR individuals.

Language: en

Keywords

Humans; Adult; Adolescent; Suicide; Young Adult; Magnetic Resonance Imaging; Pilot Projects; Suicidal Ideation; Suicidal ideation; Psychosis; MRI; Psychotic Disorders; Magnetic resonance imaging; Prodromal Symptoms; Attenuated positive symptoms; Clinical high-risk for psychosis