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Citation |
Øvlisen AK, Jakobsen LH, Kragholm KH, Nielsen RE, de Nully Brown P, Dahl-Sørensen RB, Frederiksen H, Mannering N, Josefsson PL, Ludvigsen Al-Mashhadi A, Jørgensen JM, Dessau-Arp A, Clausen MR, Pedersen RS, Torp-Pedersen C, Severinsen MT, El-Galaly TC. Am. J. Hematol. 2022; 97(6): 749-761. |
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Copyright |
(Copyright © 2022, John Wiley and Sons) |
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DOI |
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PMID |
35298039 |
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PMCID |
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Abstract |
Psychological distress following cancer diagnosis may lead to mental health complications including depression and anxiety. Non-Hodgkin lymphomas (NHLs) include indolent and aggressive subtypes for which treatment and prognosis differ widely. Incident use of psychotropic drugs (PDs-antidepressants, antipsychotics, and anxiolytics) and its correlation to lymphoma types can give insights into the psychological distress these patients endure. In this prospective matched cohort study, we used nationwide population-based registries to investigate the cumulative risk of PD use in NHL patients compared to a sex- and age-matched cohort from the Danish background population. In addition, contact patterns to psychiatric departments and incident intentional self-harm or completed suicide were explored. In total, 8750 NHL patients and 43 750 matched comparators were included (median age 68; male:female ratio 1.6). Median follow-up was 7.1 years. Two-year cumulative risk of PD use was higher in NHL patients (16.4%) as compared to the matched comparators (5.1%, p < .01); patients with aggressive NHL subtypes had the highest incidence. Prescription rates were higher in the first years after diagnosis but approached the rate of the matched population 5 years into survivorship in aggressive NHLs, whereas patients with indolent subtypes continued to be at higher risk. NHL patients had a slightly higher two-year risk of suicide/intentional self-harm (0.3%) as compared to the matched comparators (0.2%, p = .01). These results demonstrate that mental health complications among NHL patients are frequent. Routine assessment for symptoms of depression and anxiety should be consider as part of standard follow-up of NHL patients. Language: en |
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Keywords |
Humans; Aged; Female; Male; Denmark; Prospective Studies; Cohort Studies; Mental Health; Psychotropic Drugs; Lymphoma, Non-Hodgkin |