Citation

Ciesinski NK, Drabick DAG, McCloskey MS. J. Affect. Disord. 2022; 302: 367-375.

Copyright

(Copyright © 2022, Elsevier Publishing)

DOI

10.1016/j.jad.2022.01.099

PMID

35101522

Abstract

Intermittent explosive disorder (IED), the sole diagnosis in the DSM-5 for which the cardinal symptom is recurrent affective aggressive outbursts, is a common and substantially impairing disorder. IED is also associated with several cognitive and affective impairments. However, little is known about the heterogeneity of the disorder and how this may correspond to aggression severity and related adverse outcomes. The current study employed a latent class analysis (LCA) among individuals diagnosed with lifetime DSM-5 IED to derive distinct subgroups that differed in the quality and/or frequency of cognitive-affective symptoms. These subgroups were then externally validated on a number of adverse outcomes. Statistical and clinical indicators supported a four-class model. Classes were distinguished mainly by the level of emotion dysregulation participants endorsed, with two moderate emotion dysregulation classes differing on their emotional information processing and impulsive tendencies. The external validation analysis revealed that classes differed in terms of various adverse outcomes (e.g., interpersonal problems, life satisfaction, suicide risk). Overall, the present study suggests distinct cognitiveaffective symptom profiles among those with IED that differ meaningfully with regard to risk for adverse outcomes. These findings provide evidence of the heterogeneity within IED and may suggest a more personalized therapeutic approach to patients with IED.

Language: en

Keywords

Humans; Latent class analysis; Aggression; Impulsive Behavior; Anger; Emotion dysregulation; Intermittent explosive disorder; Latent Class Analysis; Disruptive, Impulse Control, and Conduct Disorders; External validation