Citation

Chan MJ, Huang CC, Hu CC, Huang WH, Hsu CW, Yen TH, Weng CH. Sci. Rep. 2020; 10(1): e8827.

Copyright

(Copyright © 2020, Nature Publishing Group)

DOI

10.1038/s41598-020-65756-w

PMID

32483235

PMCID

PMC7264308

Abstract

With increasing numbers of patients surviving acute intoxication phase, long-term complication after paraquat intoxication is a topic worth exploring, such as osteonecrosis (ON) of femoral head. We reviewed 86 paraquat-intoxicated survivors between 2000 and 2012 in Chang Gung Memorial Hospital, a 3700-bed tertiary hospital in Taiwan. With all the patients underwent same detoxification protocol in the acute stage, 17.4% of paraquat poisoning survivors developed ON of femoral head requiring surgery during follow up. Most of ON episodes occurred within 2 to 4 years after paraquat intoxication and then plateau after 6 years. ON patients exhibited higher SOFA scores than non-ON patients (2.80 ± 2.14 vs. 1.76 ± 1.52, p = 0.028). Furthermore, AKIN scores are also higher in the ON patients than non-ON patients (0.87 ± 1.13 vs. 0.38 ± 0.74, p = 0.040). Multivariate logistic regression showed higher AKIN score and higher partial pressure of carbon dioxide in the blood 48 hours after admission significantly predicted ON of femoral head after paraquat intoxication (p = 0.002 and p = 0.006 respectively). Larger studies with longer follow-up durations are warranted to confirm our finding.

Language: en

Keywords

Humans; Adult; Female; Male; Middle Aged; Severity of Illness Index; Poisoning; Retrospective Studies; Young Adult; Comorbidity; Proportional Hazards Models; Suicide, Attempted; Survivors; Follow-Up Studies; Paraquat; Taiwan; Alcoholism; Depressive Disorder, Major; Bicarbonates; Adrenal Cortex Hormones; Arthroplasty, Replacement, Hip; Carbon Dioxide; Femur Head Necrosis; Partial Pressure