Citation

Guo F, Cai J, Jia Y, Wang J, Jakšić N, Kövi Z, Sagud M, Wang W. BMC Psychiatry 2020; 20(1): e207.

Copyright

(Copyright © 2020, Holtzbrinck Springer Nature Publishing Group - BMC)

DOI

10.1186/s12888-020-02631-y

PMID

32380965

PMCID

PMC7206809

Abstract

BACKGROUND: Affective disorders, such as major depressive (MDD), bipolar I (BD I) and II (BD II) disorders, are overlapped at a continuum, but their exact loci are not clear. The self-reports from patients with affective disorders might help to clarify this issue.
METHODS: We invited 738 healthy volunteers, 207 individuals with BD I, 265 BD II, and 192 MDD to answer a 79 item-MATRIX about on-going affective states.
RESULTS: In study 1, all 1402 participants were divided random-evenly and gender-balanced into two subsamples; one subsample was used for exploratory factor analysis, and another for confirmatory factor analysis. A structure-validated inventory with six domains of Overactivation, Psychomotor Acceleration, Distraction/ Impulsivity, Hopelessness, Retardation, and Suicide Tendency, was developed. In study 2, among the four groups, MDD scored the highest on Retardation, Hopelessness and Suicide Tendency, whereas BD I on Distraction/ Impulsivity and Overactivation.
CONCLUSION: Our patients confirmed the affective continuum from Suicide Tendency to Overactivation, and described the different loci of MDD, BD I and BD II on this continuum.

Language: en

Keywords

Humans; Adult; Female; Male; Middle Aged; Adolescent; Emotions; Young Adult; Health Surveys; Suicidal Ideation; Major depressive disorder; Reproducibility of Results; Bipolar Disorder; Depressive Disorder, Major; Factor analyses; Bipolar I and II disorders; Patient report; Symptom continuum