Citation

Harsten R, Tetlow SJ, Chan T, Ankuli A. BMJ Case Rep. 2020; 13(5): e234256.

Copyright

(Copyright © 2020, BMJ Publishing Group)

DOI

10.1136/bcr-2020-234256

PMID

32414776

PMCID

PMC7232395

Abstract

A 26-year-old woman presented after an intentional ingestion of 20 g of caffeine. She suffered a profound respiratory alkalosis with metabolic acidosis, hypokalaemia and sustained polymorphic ventricular tachycardia. She was treated with intravenous intralipid and haemodialysis, and her arrhythmia was controlled using magnesium sulphate. Once invasively ventilated and unable to hyperventilate the patient became acidotic and required intravenous bicarbonate to correct her acid-base status. Two days following the overdose the patient was extubated, haemodialysis was stopped and norepinephrine was weaned off. The patient was discharged after a further 7 days. Serial caffeine levels were taken during this patient's care; the highest measured caffeine concentration 7 hours after ingestion was 147.1 mg/L. The known lethal dose of caffeine is 80 mg/L. Intralipid and haemodialysis represent a new and viable treatment in life-threatening caffeine overdose. Intravenous magnesium may terminate unstable arrhythmias in caffeine-poisoned patients.

Language: en

Keywords

Humans; Adult; Female; Drug Overdose; Suicide, Attempted; poisoning; Renal Dialysis; toxicology; cardiovascular system; Caffeine; Hypokalemia; Anti-Arrhythmia Agents; Phospholipids; Acidosis; Fat Emulsions, Intravenous; arrhythmias; Tachycardia, Ventricular; adult intensive care; Emulsions; Magnesium Sulfate; Soybean Oil