Citation

Ludvigsson J. Pediatr. Endocrinol. Rev. 2020; 17(Suppl 1): 183-190.

Copyright

(Copyright © 2020, Y. S. Medical Media)

DOI

10.17458/per.vol17.2020.l.insulinadverseevents

PMID

32208562

Abstract

The negative consequencies of diabetes treatment are traditionally regarded as caused by a disastrous treatment rather than adverse events of the insulin preparations. However, hypoglycemia, changes at the injection site (lipatrophy, lipoma), insulin allergy, obesity and increased risk of certain forms of cancer can easily be regarded as adverse events of the drug, and needle-phobia, psychological problems, increased risk of suicide are adverse events related to insulin and its administration. Also macroangiopathy and even microangiopathy to some extent can be regarded as adverse events as the most crucial part of the treatment of Type 1 diabetes is the insulin treatment. There is still room for improvments of insulin as a drug. We need insulins with more predictable absorption and kinetics, leading to more stable near-normal blood glucose, less risk of hypoglycemia, less effect in periphery and more effect on the liver, and less risk of vascular complications, obesity, cancer.

Language: en

Keywords

Humans; Obesity; Adverse events; Hypoglycemia; Hypoglycemic Agents; Insulin; Cancer; Diabetes Mellitus, Type 2; Blood Glucose; Insulin allergy; Insulin antibodies; Lipo-atrophy; Lipo-hypertrophy