Citation

Greene RD, Cook A, Nowaskie D, Wang S. Clin. Geriatr. Med. 2020; 36(2): 297-313.

Copyright

(Copyright © 2020, Elsevier Publishing)

DOI

10.1016/j.cger.2019.11.009

PMID

32222303

Abstract

This article covers current research on the relationship between depression and cognitive impairment in older adults. First, it approaches the clinical assessment of late-life depression and comorbid cognitive impairment. Cognitive risk factors for suicide are discussed. Research is then provided on neuropsychological changes associated with depression, discussing subjective cognitive impairment, mild cognitive impairment, and dementia profiles. In addition, literature regarding neuroimaging and biomarker findings in depressed older adults is presented. Finally, therapeutic models for treatment of late-life depression are discussed, including psychotherapy models, holistic treatments, pharmacologic approaches, and brain stimulation therapies.

Language: en

Keywords

Humans; Aged; Neuropsychological Tests; Neuroimaging; Major depressive disorder; Antidepressants; Psychotherapy; Aging; Depressive Disorder, Major; Mild cognitive impairment; Cognitive Dysfunction; Neurocognitive disorder; Neuropsychological testing; Patient Care Management; Subjective cognitive impairment