Citation

Liu MN, Tsai SJ, Yeh HL, Wu CC, Lin CP. Arch. Suicide Res. 2020; 24(3): 467-476.

Copyright

(Copyright © 2020, International Academy of Suicide Research, Publisher Informa - Taylor and Francis Group)

DOI

10.1080/13811118.2019.1649772

PMID

32000634

Abstract

OBJECTIVES: We compared serum levels of chemokines between male elders with major depressive disorder (MDD) and healthy controls, verifying whether any difference exists in the levels of these mediators between those with and without current suicidal ideation (SI).
METHODS: We enrolled 145 male elders aged 65 or older and analyzed 40 chemokines in patients with MDD with SI (n = 24) and without SI (n = 23), as well as healthy controls (n = 98).
RESULTS: The patients with MDD with SI presented higher levels of MCP-2/CCL8 (p < 0.001) compared with the patients with MDD without SI and the healthy controls.
CONCLUSIONS: Current findings suggest a potential role of MCP-2/CCL8 in suicidality among elderly males with depression.

Language: en

Keywords

Humans; Male; suicide; Suicide; Aged, 80 and over; elderly; Psychiatric Status Rating Scales; Suicidal Ideation; Suicide Prevention; major depressive disorder; Antidepressive Agents; Taiwan; Diagnostic and Statistical Manual of Mental Disorders; Geriatric Assessment; Depressive Disorder, Major; Chemokines; Correlation of Data; Chemokine CCL8; Immunologic Tests; MCP-2/CCL8