Citation

Lee DU, Chou H, Wang E, Fan GH, Han J, Chang K, Kwon J, Lee KJ, Blanchard J, Urrunaga NH. Expert Rev. Gastroenterol. Hepatol. 2022; 16(7): 689-697.

Copyright

(Copyright © 2022, Expert Reviews)

DOI

10.1080/17474124.2022.2090337

PMID

35708303

PMCID

PMC9344485

Abstract

BACKGROUND: In this study, we evaluate the clinical impact of psychiatric illnesses (PI) on the hospital outcomes of patients admitted with alcoholic liver disease (ALD).

METHODS: From the National Inpatient Sample from 2012-2017, patients with alcoholic cirrhosis or alcoholic hepatitis were selected and stratified using the presence/absence of PI (which was a composite of psychiatric conditions). The cases were propensity score-matched to PI-absent controls and were compared to the following endpoints: mortality, death due to suicide, length of stay (LOS), hospitalization charges, and hepatic complications.

RESULTS: After matching, there were 122,907 PI with and 122,907 without PI. Those with PI were younger (51.8 vs. 51.9 years p = 0.02) and more likely to be female (39.2 vs. 38.7% p = 0.01); however, there was no difference in race. Patients with PI had lower rates of alcoholic cirrhosis but higher rates of alcoholic hepatitis/alcoholic hepatic steatosis. In multivariate, patients with PI had lower rates of all-cause mortality (aOR 0.51 95%CI 0.49-0.54); however, they experienced higher rates of deaths due to suicide (aOR 3.00 95%CI 1.56-5.78) and had longer LOS (aOR 1.02 95%CI 1.01-1.02).

CONCLUSION: Presence of PI in ALD patients is associated with prolonged hospital stay and higher rates deaths due to suicide.

Language: en

Keywords

Humans; Female; Male; Retrospective Studies; bipolar disorder; depression; schizophrenia; anxiety; Hospitals; *Hepatitis, Alcoholic/diagnosis/epidemiology; *Liver Diseases, Alcoholic/complications/epidemiology; *Mental Disorders/complications; Alcoholic hepatitis; Liver Cirrhosis, Alcoholic/diagnosis/epidemiology; PI