Citation

Wu J, Liu Z. Intern. Emerg. Med. 2022; 17(7): 2069-2081.

Copyright

(Copyright © 2022, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s11739-022-03079-6

PMID

36028733

PMCID

PMC9417090

Abstract

Colchicine is a tricyclic, lipid-soluble alkaloid which has long been used to treat gout and many immunological diseases. Due to its narrow therapeutic window and long half-life of elimination, colchicine overdose occurs occasionally. Unfortunately, some patients lost their lives because of colchicine overdose or suicide. Acute colchicine poisoning can lead to original gastrointestinal disorders, shock, progressive multiple organ failure, and myelosuppression. Although many researchers in the world performed lots of research, there are currently no specific antidotes for colchicine poisoning. Meanwhile, there are no management guidelines to treat patients with acute colchicine poisoning until now. Herein, we systematically elaborate on the clinical features and progress in the management of acute colchicine poisoning in adults according to the previous literature. This paper will provide some valuable and available information for clinicians.

Language: en

Keywords

Humans; Adult; *Suicide; Lipids; Multiple Organ Failure; Extracorporeal life support; Colchicine poisoning; Multiple organ dysfunction; *Poisoning/drug therapy; Antidotes/therapeutic use; Blood perfusion; Colchicine/therapeutic use; Management strategy; Myelosuppression