Citation

Angulo NY, Castaño PA, Gómez CC, Quintero S. Biomedica 2022; 42(3): 445-449.

Copyright

(Copyright © 2022, Instituto Nacional de Salud of Colombia)

DOI

10.7705/biomedica.6428

PMID

36122284

PMCID

PMC9552747

Abstract

Neuroleptic malignant syndrome is a rare and potentially fatal clinical condition frequently associated with the use of antipsychotics. In the literature, there is only one case report associated with the intake of organophosphates. We present the case of a patient who presented with a clinical picture compatible with neuroleptic malignant syndrome, after the ingestion of an organophosphate (chlorpyrifos). A 57-year-old man who consulted for attempted suicide, acute deterioration of consciousness, torpid neurological evolution, and associated autonomic instability associated with rigidity, persistent hyperthermia, and elevated CPK. Bromocriptine treatment was offered, which resolved the clinical picture. The association with the ingestion of an organophosphate was established, and he was discharged without sequelae. The diagnosis of neuroleptic malignant syndrome is clinical and should be considered in any case of exposure to substances that may lead to dysregulation of dopaminergic neurotransmission in order to initiate timely therapy and impact outcomes.

Language: es

Keywords

Humans; Male; Middle Aged; organophosphate; rhabdomyolysis; fever; bromocriptine; Neuroleptic malignant syndrome; insecticides; *Antipsychotic Agents/adverse effects; *Chlorpyrifos/therapeutic use; *Neuroleptic Malignant Syndrome/diagnosis/etiology/therapy; *Organophosphate Poisoning/complications; Bromocriptine/therapeutic use; cholinesterases