Citation

Ilari S, Passacatini LC, Malafoglia V, Oppedisano F, Maiuolo J, Gliozzi M, Palma E, Tomino C, Fini M, Raffaeli W, Mollace V, Muscoli C. Pharmacol. Res. 2022; 186: 106547.

Copyright

(Copyright © 2022, Elsevier Publishing)

DOI

10.1016/j.phrs.2022.106547

PMID

36336218

Abstract

Widespread musculoskeletal pain characterizes fibromyalgia (FM), accompanied by sleep, fatigue, and mood problems. Chronic stress and depression play a crucial role in the etiology and pathophysiology of FM. They may contribute to a dysregulation of the central pain mechanisms together with the neuroendocrine and immune systems. Pharmacological treatments are the first-line therapy to reduce the symptoms of FM. The US Food and Drug Administration (FDA) indicated gabapentinoid, pregabalin, duloxetine, and milnacipran for adult patients. An alternative approach is widely used, based on therapies including interventions in patient education, behavioral therapy, exercise, pain management, and a healthy diet. A systematic search was performed on PubMed, MEDLINE, EMBASE, and Web of Science databases. The authors established the selection, inclusion, and exclusion criteria. We found a total of 908 articles. This systematic review will include ten articles selected after excluding duplicates and reading the abstracts and full texts. All studies related the effect of drugs to various symptoms caused by fibromyalgia patients with depression, such as insomnia/sleepiness, depression, suicide, difficulty walking/working, pain, fatigue, and nervousness. Although, we concluded that antidepressant drugs are effective in treating depression and pain in fibromyalgia, further studies are needed to understand the etiology of this disease and to find a combination of therapies to increase tolerability and adherence of the patient to the drug, decreasing the adverse effects.

Language: en

Keywords

Humans; Adult; Depression; Chronic pain; Employment; Antidepressant; Fibromyalgia; *Fibromyalgia/drug therapy; *Musculoskeletal Pain/drug therapy; Amitriptyline (Pubchem CID:2160); Antidepressive Agents/adverse effects; Citalopram (Pubchem CID: 2771); Desvenlafaxine (Pubchem CID: 125017); Duloxetine (Pubchem CID: 60835); Escitalopram (Pubchem CID: 146570); Fatigue/drug therapy; Fibromyalgia treatment; Fluoxetine (Pubchem CID: 3386); Milnacipran (Pubchem CID: 65833); Paroxetine (Pubchem CID: 43815); Pregabalin (Pubchem CID: 5486971); Saffron (Pubchem CID: 5281233); Sertraline (Pubchem CID: 68617); Trazodone(Pubchem CID: 5533); Venlafaxine (Pubchem CID: 5656); Vitamin D (Pubchem CID:D5280793)