Citation

Programa de Identidade de GêneroReal AG, Programa de Identidade de GêneroFontanari AMV, Costa AB, Programa de Identidade de GêneroSoll BMB, INCT Translacional em MedicinaBristot G, INCT Translacional em Medicinade Oliveira LF, Programa de Identidade de GêneroKamphorst AM, Programa de Identidade de GêneroSchneider MA, Programa de Identidade de GêneroLobato MIR. Trends in psychiatry and psychotherapy 2021; 43(1): 37-46.

Copyright

(Copyright © 2021, Associação de Psiquiatria do Rio Grande do Sul)

DOI

10.47626/2237-6089-2020-0007

PMID

unavailable

Abstract

Introduction Gender dysphoria (GD) is characterized by a marked incongruence between experienced gender and one's gender assigned at birth. Transsexual individuals present a higher prevalence of psychiatric disorders when compared to non-transsexual populations, and it has been proposed that minority stress, i.e., discrimination or prejudice, has a relevant impact on these outcomes. Transsexuals also show increased chances of having experienced maltreatment during childhood. Interleukin (IL)-1β, IL-6, IL-10 and tumor necrosis factor-alpha (TNF-α) are inflammatory cytokines that regulate our immune system. Imbalanced levels in such cytokines are linked to history of childhood maltreatment and psychiatric disorders. We compared differences in IL-1β, IL-6, IL-10 and TNF-α levels and exposure to traumatic events in childhood and adulthood in individuals with and without GD (DSM-5).

METHODS Cross-sectional controlled study comparing 34 transsexual women and 31 non-transsexual men. They underwent a thorough structured interview, assessing sociodemographic information, mood and anxiety symptoms, childhood maltreatment, explicit discrimination and suicidal ideation. Inflammatory cytokine levels (IL-1β, IL-6, IL-10 and TNF-α) were measured by multiplex immunoassay.

RESULTS Individuals with GD experienced more discrimination (p = 0.002) and childhood maltreatment (p = 0.046) than non-transsexual men. Higher suicidal ideation (p < 0.001) and previous suicide attempt (p = 0.001) rates were observed in transsexual women. However, no differences were observed in the levels of any cytokine.

CONCLUSIONS These results suggest that transsexual women are more exposed to stressful events from childhood to adulthood than non-transsexual men and that GD per se does not play a role in inflammatory markers.

Language: en

Keywords

Discrimination; Childhood maltreatment; Case-control study; Gender dysphoria; Inflammatory cytokines; Transsexuality