Citation

Chen P, Chen Z, Xu L. China Oncology 1998; (12).

Copyright

(Copyright © 1998)

DOI

unavailable

PMID

unavailable

Abstract

PURPOSE:To investigate the antitumor effect of 5-fluorocytosine/cytosine deaminase (5FC/CD) suicide gene system combined with heat shock protein 70 peptide complexes(HSP70-PC) tumor vaccine.

METHODS:5-FC was administrated intraperitoneally after recombinant adenoviruses carrying E.coli CD gene were injected into murine tumor tissue. At the same time,mice bearing tumor were inoculated s.c. with HSP70-PC.

RESULTS:The combined therapy led to reduction in tumor growth, and complete tumor regression was observed in 70% of the mice. After the combined therapy, the tumor tissue showed more CD + 4 and CD + 8T cells infiltration, and the murine CTL activities increased significantly.

CONCLUSIONS:The therapy combining 5-FC/CD system with HSP-PC tumor vaccine is very effective in murine gastric cancer, and has potential for clinical usage.

Language: zh

Keywords

suicide gene; MFC gastric cancer cells; shock protein 70-peptide complexes