Citation

Cho SJ, Park JK, Yeo DG, Jeong YD, Cheo JY, Ahn KS, Lee JH, Sohn HS. Kor. J. Nephrol, 2000; 542-546.

Copyright

(Copyright © 2000)

DOI

unavailable

PMID

unavailable

Abstract

Doxylamine succinate is common over-the-counter sleep medication that is frequently involved in accidental poisonings and suicide attempts. Doxylamine overdose is generally directed at the anticholinergic effect including autonomic,and central nervous system effect and direct cardiac toxicity. Rarely, rhabdomyolysis has been reported with doxylamine overdose. We experienced two cases of rhabdomyolysis with overdose of doxylamine in 17-year-old and 31-year-old male. They were diagnosed with high levels of creatine phosphokinase in serum, myoglobin in serum and urine, and increased radionuclide uptake of muscles in (99m)Tc-MDP bone scan. Patients recovered without any complications with hydration and diuresis. Clinicians should be aware of the possibility of rhabdomyolysis in patients with doxylamine overdose.

Language: ko

Keywords

Acute renal failure; Rhabdomyolysis; Doxylamine