Citation

Lee JG, Seo MK, Park SW, Baek JH, Kim YH. Korean Journal of Psychopharmacology 2012; 147-154.

Copyright

(Copyright © 2012, Taehan Chongshin Yakmul Hakhoe)

DOI

unavailable

PMID

unavailable

Abstract

Depression is a common psychiatric illness with a high lifetime prevalence in the general population. Serious problem, such as suicide is commonly occurring in the patients with depression. Till now, the monoamine hypothesis has been the most popular theory of pathogenesis for depression. However, the more specific pathophysiology of depression and cellular molecular mechanism underlying action of commercial antidepressant has not been clearly defined. Several recent studies demonstrated that neural plasticity, epigenetic and mammalian target of rapamycin signaling are promising answers to the pathophysiology of depression. In this article, current understanding of biology and molecular mechanisms of depression and new research on the pathophysiology of depression will be discussed.

Language: ko

Keywords

Depression; Pathophysiology; mTOR signaling; Monoamine hypothesis; Neural plasticity