Citation

Xie Y, Hou X, Wu C. Chinese Journal of Information on Traditional Chinese Medicine 2017; (12): 125-129.

Copyright

(Copyright © 2017)

DOI

10.3969/j.issn.1005-5304.2017.03.031

PMID

unavailable

Abstract

s:Apoptosis, also known as programmed cell death, is a gene controlled active cell suicide process in order to maintain balance of organisms. Apoptosis is mainly mediated through three signal pathways, including the endoplasmic reticulum, mitochondria, and death receptor. As a kind of naphthoquinone compounds and one of the main active ingredients of Lithospermum, shikonin has many biological activities, and its anti-cancer research is recent hot spot. The anti-cancer mechanism of shikonin is closely related with apoptosis and three kinds of signaling pathways. This article reviewed the research progress in apoptosis and signal pathways induced by shikonin.

Language: zh

Keywords

review; apoptosis; shikonin; signal pathway