Citation

Ortelbach N, Rote J, Dingelstadt AML, Stolzenburg A, Koenig C, O'Malley G, Quinlivan E, Fiebig J, Pfeiffer S, Konig B, Simhandl C, Bauer M, Pfennig A, Stamm TJ. Int. J. Bipolar Disord. 2022; 10(1).

Copyright

(Copyright © 2022, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1186/s40345-021-00248-y

PMID

unavailable

Abstract

BACKGROUND: Using a personality typing approach, we investigated the relationship between personality profiles and the prediction of longterm illness severity in patients with bipolar disorder (BD). While previous research suggests associations between BD and traits from the NEO-FFI profiles, the current study firstly aimed to identify latent classes of NEO-FFI profiles, and, secondly, to examine their impact on the longterm prognosis of BD.

METHODS: Based on the NEO-FFI profiles of 134 euthymic patients diagnosed with BD (64.2% female, mean age = 44.3 years), successive latent profile analyses were conducted. Subsequently, a subsample (n = 80) was examined prospectively by performing multiple regression analysis of the latent classes to evaluate the longitudinal course of the disease (mean: 54.7 weeks) measured using a modified Morbidity Index.

RESULTS: The latent profile analyses suggested a 3-class model typifying in a resilient (n = 68, 51%), vulnerable (n = 55, 41%) and highly vulnerable (n = 11, 8%) class. In the regression analysis, higher vulnerability predicted a higher longterm Morbidity Index (R2 = 0.28).

CONCLUSIONS: Subgroups of patients with BD share a number of discrete personality features and their illness is characterized by a similar clinical course. This knowledge is valuable in a variety of clinical contexts including early detection, intervention planning and treatment process. © 2022, The Author(s).

Language: en

Keywords

adult; human; female; male; quality of life; bipolar disorder; Bipolar disorder; depression; substance use; scoring system; suicide attempt; hospitalization; comorbidity; disease severity; psychoeducation; alcohol consumption; major clinical study; mental disease; controlled study; statistical analysis; psychologic assessment; neurosis; follow up; multicenter study; mania; prospective study; DSM-IV; extraversion; mental function; Article; Structured Clinical Interview for DSM Disorders; parsimony analysis; Young Mania Rating Scale; Illness course; Big five; sleep quality; Hamilton Depression Rating Scale; Likert scale; conscientiousness; latent profile analysis; openness; agreeableness; Big Five Inventory; longterm illness severity; Morbidity index; Morbidity Index; Personality typology