Citation

Wu XH, Wang JM. Chinese Traditional and Herbal Drugs 2022; 53(17): 5531-5543.

Copyright

(Copyright © 2022)

DOI

10.7501/j.issn.0253-2670.2022.17.031

PMID

unavailable

Abstract

Depression has the huge social harm of high incidence, high disability, and high fatality rate, and its incidence rate in the diabetic population is 2 to 3 times of that in the normal population. The combination of the two diseases caused and aggravated a variety of physical functions and psychological disorders in patients, and increased the suicide rate. Traditional Chinese medicine has the advantages of holistic treatment, small side effects, and significant curative effects in the prevention and treatment of diabetic depression. However, its scientific connotation is not very clear, and the relevant modern research and promotion and application are still very weak. Pathogenesis of diabetic depression, and modern animal and clinical research on prevention and treatment of diabetic depression by traditional Chinese medicine prescription, single traditional Chinese medicine, and traditional Chinese medicine ingredients were reviewed in this paper. Combining with modern research status of traditional Chinese medicine in treatment of diabetic depression, it is suggested that clinical effect of traditional Chinese medicine compound should be taken as the guidance in the future, and study on "sovereign", "minister", "assistant' and "guiding" medicinal in the effective prescriptions and their active ingredients in prevention and treatment of diabetic depression should be strengthened to provide a basis for the elucidation of material basis and target of traditional Chinese medicine compound, in order to provide a certain reference value for experimental study and clinical application of diabetic depression. © 2022 Editorial Office of Chinese Traditional and Herbal Drugs. All rights reserved.

Language: zh

Keywords

depression; pathogenesis; clinical research; prescription; nonhuman; drug effect; diabetes mellitus; Article; Chinese drug; Chinese medicine; clinical application; diabetic depression; effect target; pharmacologic actions; traditional Chinese medicine