Citation

He M, Ping L, Chu Z, Zeng C, Shen Z, Xu X. Front. Neurosci. 2022; 16.

Copyright

(Copyright © 2022, Frontiers Research Foundation)

DOI

10.3389/fnins.2022.856366

PMID

unavailable

Abstract

OBJECTIVE: Adult patients with major depressive disorder (MDD) may not actively reveal their suicidal ideation (SI). Therefore, this study is committed to finding the alterations in the cingulo-opercular network (CON) that are closely related to SI with multi-imaging methods, thus providing neuroimaging basis for SI.

METHOD: A total of 198 participants (129 MDD patients and 69 healthy controls) were recruited and evaluated with the Montgomery-Asberg Depression Rating Scale (MADRS). The healthy individuals formed the HC group, while the MDD patients were subdivided into no SI MDD (NSI, n = 32), mild SI MDD (MSI, n = 64), and severe SI MDD (SSI, n = 33) according to their MADRS item 10. We obtained MRI data of all participants and applied regional homogeneity (ReHo) analysis to verify a previous finding that links CON abnormality to SI. In addition, we employed the structural covariance network (SCN) analysis to investigate the correlation between abnormal structural connectivity of CON and SI severity.

RESULTS: Compared to those of the HC group, MDD ReHo values and gray matter volume (GMV) were consistently found abnormal in CON. ReHo values and GMV of the right orbital inferior frontal gyrus (ORBinf.R) in the MDD group decreased with the increase of SI. Compared to the HC group, the MDD patients showed enhanced structural connectivity of three pairs of brain regions in CON [ACC.L-left superior frontal gyrus (SFG.L), SFG.L-left middle temporal gyrus (MTG.L), and the SFG.L-left post-central gyrus (PoCG.L)]. Compared with that of the NSI and MSI groups, the structural connectivity of three pairs of brain regions in CON is enhanced in the SSI groups [ORBinf.L-right ventral posterior cingulate gyrus (VPCC.R), VPCC.R-SFG.R, and SFG.R-PoCG.R].

CONCLUSION: Our findings showed the distinctive ReHo, GMV, and SCN pattern of CON in MDD patients with SI; and with the severity of suicide, abnormal brain regions increased. Our finding suggested that MDD patients with different severity of SI have different neuroimaging changes. Copyright © 2022 He, Ping, Chu, Zeng, Shen and Xu.

Language: en

Keywords

adult; human; female; male; image analysis; suicidal ideation; white matter; functional magnetic resonance imaging; major depressive disorder; major depression; disease severity; neuroimaging; major clinical study; controlled study; disease association; human tissue; neuropathology; correlation analysis; brain function; DSM-IV; brain size; disease duration; thalamus; Montgomery Asberg Depression Rating Scale; basal ganglion; Article; cerebellum; temporal lobe; left hemisphere; right hemisphere; Hamilton Anxiety Scale; gray matter; image processing; parietal lobe; anterior cingulate; posterior cingulate; superior frontal gyrus; echo planar imaging; middle frontal gyrus; three-dimensional imaging; structural connectivity; inferior frontal gyrus; image segmentation; functional MRI; regional homogeneity; middle temporal gyrus; postcentral gyrus; cingulo opercular network; structure connectivity