Citation

Ba Z, Chen M, Lai J, Liao Y, Fang H, Lu D, Zheng Y, Zong K, Lin X. Front. Psychiatry 2022; 13.

Copyright

(Copyright © 2022, Frontiers Media)

DOI

10.3389/fpsyt.2022.900757

PMID

unavailable

Abstract

OBJECTIVE: This study aims to identify the functional heterogeneity in fully or partially remitted patients with bipolar disorder and explore the correlations between psychosocial functioning and sociodemographic, clinical, neurocognitive and biochemical variables.

METHODS: One hundred and forty fully or partially remitted patients with bipolar disorder (BD) and seventy healthy controls were recruited. The patients were grouped into different profiles based on the Functioning Assessment Short Test (FAST) domain scores by hierarchical cluster analysis. The characteristics of subgroups and the correlations between psychosocial functioning and sociodemographic, clinical, neurocognitive and biochemical variables in each cluster were then analyzed.

RESULTS: There were three subgroups in fully or partially remitted patients with BD: the lower functioning group (LF), performed global functioning impairments; the moderate functioning group (MF), presented selective impairments in functional domains; and the good functioning subgroup (GF), performed almost intact functioning. Among the three subgroups, there were differences in FAST domains, sociodemographic variables, clinical variables, some neurocognitive domains and several biochemical indexes.

CONCLUSIONS: The study successfully identified three functional subgroups. The characteristics of discrete subgroups and the specific clinical factors, neurocognitive domains and biochemical indexes that are correlated with functional subgroups will allow for making tailored interventions to promote functional recovery and improve the quality of life. Copyright © 2022 Ba, Chen, Lai, Liao, Fang, Lu, Zheng, Zong and Lin.

Language: en

Keywords

adolescent; adult; human; cognition; age; female; male; quality of life; bipolar disorder; suicidal ideation; depression; psychosis; scoring system; hospitalization; major clinical study; controlled study; attention; disease classification; antidepressant agent; neuroleptic agent; socioeconomics; blood sampling; lipid metabolism; triacylglycerol; functional assessment; human relation; social psychology; leisure; statistical significance; lithium carbonate; albumin; personal autonomy; family history; psychometry; benzodiazepine derivative; cross-sectional study; demography; benzodiazepine; reliability; onset age; low density lipoprotein cholesterol; valproic acid; mania; financial management; lamotrigine; symptom; correlation analysis; remission; oxcarbazepine; drug indication; cluster analysis; biochemistry; high density lipoprotein cholesterol; protein; liothyronine; body mass; thyroxine; Article; validity; biological marker; working memory; medical history; clinical assessment; treatment duration; trihexyphenidyl; functional status; Young Mania Rating Scale; visual memory; DSM-5; Stroop test; Hamilton Depression Rating Scale; Likert scale; processing speed; neurocognition; trail making test; Wechsler memory scale; Beck scale; biochemical index; Digit Symbol Coding; Digital Span Backward subtest; Digital Span Forward subtest; functional recovery; Functioning Assessment Short Test; global functioning impairment; good functioning; hierarchical clustering; lower functioning; moderate functioning; psychosocial functioning; suicide ideation scale; Visual Recognition subtest; Visual Reproduction subtest