Citation

Crespi J, Gulati S, Salvesen, Bratbak DF, Dodick DW, Matharu MS, Tronvik E. Cephalalgia Reports 2022; 5.

Copyright

(Copyright © 2022)

DOI

10.1177/25158163221075569

PMID

unavailable

Abstract

BACKGROUND: Cluster headache (CH) is one of the most painful conditions in humans and there is limited epidemiological data on this debilitating condition.

OBJECTIVES: To describe the epidemiology of CH in Norway Methods: We conducted a nationwide study to investigate the prevalence, incidence, and comorbidity of CH in Norway between January 1 2008 and December 31 2016. Treatment and outcome data from the Norwegian patient registry and the Norwegian prescription database were linked on an individual basis.

RESULTS: Among 3,892,260 individuals ≥18 years old of age, we identified a total of 1891 patients with CH. The prevalence of CH was 48.6 per 100,000, and the male-to-female ratio was 1.47. The estimated incidence of CH was 3.0 per 100,000/year. Among patients with CH, increased age and sex adjusted odds ratios ([OR], all with p-values <0.0001, were observed for medication-induced headache (OR 50.7, 95% CI 36.7-69.9), migraine (OR 25.2, 95% CI 22.5-28.3), chronic posttraumatic headache (OR 22.2, 95% CI 12.8-38.45), history of cranial trauma (OR 1.9, 95% CI 1.5-2.4), somatoform disorders (OR 4.2, 95% CI 3.0-5.8), suicide attempt (OR 3.9, 95% CI 2.6-5.8), personality disorder (OR 3.6, 95% CI 2.6-4.9), bipolar disorder (OR 3.6, 95% CI 2.8-4.8), peptic ulcer (OR 2.8, 95% CI 2.3-3.3), depression (OR 2.8, 95% CI 2.4-3.1), substance abuse (OR 2.6, 95% CI 2.0-3.3), and cerebrovascular disease (OR 2.4, 95% CI 1.8-3.1). Use of opioid analgesics during the study period was more common among patients with CH compared to others (81% vs. 22%, sex and age adjusted OR 23.4, 95% CI 20.8-26.2, p < 0.0001). © The Author(s) 2022.

Language: en

Keywords

adult; Norway; human; female; male; epidemiology; incidence; head injury; bipolar disorder; depression; prevalence; suicide attempt; comorbidity; substance abuse; migraine; major clinical study; personality disorder; cerebrovascular disease; sumatriptan; Article; somatoform disorder; cluster headache; outcome assessment; prednisolone; indometacin; peptic ulcer; chronic post traumatic headache; medication induced headache