Citation

Fernández-Miranda JJ, Díaz-Fernández S, López-Muñoz F. J. Pers. Med. 2022; 12(7).

Copyright

(Copyright © 2022, MDPI: Multidisciplinary Digital Publishing Institute)

DOI

10.3390/jpm12071101

PMID

unavailable

Abstract

Case management is a model of personalized intervention in people with severe mental illness. To explore the treatment adherence and effectiveness of patients with severe schizophrenia (Clinical Global Impression Severity, CGI-S ≥ 5) undergoing treatment in a community-based, casemanaged program (CMP) with an integrated pharmacological and psychosocial approach compared with the standard treatment, an observational, ten-year follow-up study was conducted on patients treated in mental health units (MHUs) or a CMP (n = 688). Treatment discontinuation, hospitalizations, suicide attempts, and antipsychotic (AP) medications were recorded. Clinical severity was assessed with the CGI-S. Adherence to the CMP was higher than adherence to standard treatment (p < 0.001). There were fewer hospitalizations and suicide attempts in the CMP (p < 0.001). The clinical severity decreased more in the CMP (p < 0.005). Long-acting injectable (LAI) antipsychotic medication was more closely related to these outcomes than oral antipsychotics (APs) were (p < 0.001). Patients with severe schizophrenia in an integrated CMP recorded higher treatment compliance and better outcomes compared with standard care. Treatment with LAI APs was linked to these outcomes. A personalized combination of case management and LAI AP medication was more effective in these patients than standard treatment and oral APs. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Language: en

Keywords

adult; human; mental health; suicide; female; male; Review; treatment; schizophrenia; psychosis; suicide attempt; hospitalization; longitudinal study; adherence; major clinical study; controlled study; health care quality; hospital admission; mental health service; follow up; mental health center; ICD-10; outcomes; disease duration; case management; observational study; outcome assessment; clinical assessment; Clinical Global Impression scale; cognitive remediation therapy; hospital admissions; long-acting antipsychotic; personalized