Citation

Mishra S, Shekunov J, Derscheid DJ, Canterbury EA, Leung JG. Case Rep. Psychiatry 2022; 2022.

Copyright

(Copyright © 2022, Hindawi Publishing)

DOI

10.1155/2022/2149301

PMID

unavailable

Abstract

Guanfacine is a selective alpha-2a adrenoreceptor agonist that with overdose can cause symptoms ranging from mild sedation to coma, respiratory depression, hyporeflexia, hypotonia, bradycardia, and hypotension. Despite a well-defined and predictable toxidrome, variations can be seen based on multiple factors including age, quantity ingested, organ functions, coingestions, time since ingestion, and specific dosage form. Here, we describe two cases of delayed presentation of extended release guanfacine toxicity and highlight the variations encountered in the toxidrome presentation. These cases bring to attention the importance of maintaining a high suspicion for such atypical presentations, keeping in mind the limitations of managing these complications on an inpatient psychiatric unit. © 2022 Sanskriti Mishra et al.

Language: en

Keywords

adolescent; human; case report; psychotherapy; depression; anxiety; suicide attempt; hospitalization; drug overdose; prescription; clinical article; hospital admission; amfebutamone; citalopram; tachycardia; headache; impulsiveness; language disability; learning disorder; nausea; hypotension; psychosocial disorder; sodium chloride; hypertension; escitalopram; heart rate; tablet; electrocardiography; bradycardia; diplopia; dizziness; slurred speech; kidney function; Article; systolic blood pressure; speech disorder; patient assessment; hospital readmission; hydralazine; sinus bradycardia; guanfacine; hemoconcentration; rapid response team