Citation

Peng HL, Liu LN, Liu DL, Tan YY. World Chinese Journal of Digestology 2022; 30(7): 295-302.

Copyright

(Copyright © 2022)

DOI

10.11569/wcjd.v30.i7.295

PMID

unavailable

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, and is closely related to the high incidence of obesity, metabolic syndrome, type 2 diabetes, arteriosclerotic cardiovascular disease, and colorectal tumor. Depression is a common mental disorder that is characterized by high incidence, high recurrence rate, high disability rate, and high suicide rate, which has serious harm to patients' physical and mental health, reduce the quality of life of patients. In recent years, as more and more attention has been paid to mental health of NAFLD patients, the relationship between NAFLD and depression has become one of the hot research topics. Studies have shown that the incidence of depression in NAFLD patients is higher than that in non-NAFLD patients, and the incidence of NAFLD in depressed patients is also higher. Some research results have been published on the mechanism of comorbidity between the two. This paper reviews the research progress on the correlation and common mechanism between NAFLD and depression, aiming to lay a foundation for further research on the comorbidities of NAFLD and depression, and provide a basis and research direction for the diagnosis and treatment of patients with both comorbidities. © The Author(s) 2022.

Language: zh

Keywords

human; mental health; Depression; suicide; incidence; quality of life; depression; comorbidity; disease association; Article; nonalcoholic fatty liver; Pathogenesis; Non-alcoholic fatty liver disease