Citation

Zhu ZH, Song XY, Man LJ, Chen P, Tang Z, Li RH, Ji CF, Dai NB, Liu F, Wang J, Zhang J, Jia QF, Hui L. Front. Psychiatry 2022; 13.

Copyright

(Copyright © 2022, Frontiers Media)

DOI

10.3389/fpsyt.2022.858675

PMID

unavailable

Abstract

OBJECTIVE: The interleukin-8 (IL-8) has been reported to play an important role in depression, which might be modulated by the selective serotonin reuptake inhibitors (SSRIs). Thus, the aim of this study was to investigate serum IL-8 levels, depressive symptom, and their associations in drug-free MDD patients, MDD patients with SSRIs, and healthy controls (HCs).

METHODS: Fifty-seven drug-free MDD patients (male/female = 35/22, mean age: 39.24 years), 30 MDD patients with SSRIs (male/female = 11/19, mean age: 39.73 years), and 101 HCs (male/female = 52/49, mean age: 37.38 years) were recruited in this cross-sectional study. Serum IL-8 levels and depressive symptom were assessed using the Flow Cytometer and Hamilton Depression Scale (HAMD). The analysis of variance was used for the comparison between groups. The relationship between serum log10 IL-8 levels and HAMD score was analyzed by Pearson correlation.

RESULTS: Serum log10IL-8 levels were lower in all patients than HCs after controlling for covariates (F = 4.86, p = 0.03). There was significant difference in serum Log10IL-8 levels among three groups after controlling for covariates (F = 14.63, p < 0.001). Serum Log10IL-8 levels in drug-free patients were lower compared to HCs (F = 19.38, p < 0.001) or patients with SSRIs (F = 21.89, p < 0.001) after controlling for covariates. However, there was not difference in serum log10IL-8 levels between patients with SSRIs and HCs after controlling for covariates. Moreover, serum Log10IL-8 levels were negatively correlated with HAMD score in all patients (r = −0.37, p = 0.02). Also, serum Log10IL-8 levels were negatively correlated with HAMD score in drug-free patients (r = −0.74, p = 0.01), but not in patients with SSRIs.

CONCLUSION: Our data supported that the decline in serum IL-8 levels was association with depression. Moreover, the SSRIs might modulate increased serum IL-8 levels of depression. Copyright © 2022 Zhu, Song, Man, Chen, Tang, Li, Ji, Dai, Liu, Wang, Zhang, Jia and Hui.

Language: en

Keywords

adult; human; suicide; female; male; education; scoring system; major depressive disorder; major depression; association; major clinical study; controlled study; smoking; serotonin uptake inhibitor; drinking; health status; cross-sectional study; onset age; protein blood level; body mass; analysis of variance; correlation coefficient; Article; SSRIs; analysis of covariance; interleukin 8; flow cytometry; Hamilton Depression Rating Scale; Han Chinese; depressive symptom; interleukin-8