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Abstract
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OBJECTIVE To investigate the clinical characteristics and causes of neurological and mental adverse drug reaction (ADR) induced by montelukast.
METHODS Such databases as CNKI, Wanfang, VIP and PubMed were searched for related articles published from the inception of databases to February 29, 2020. Case reports and clinical studies on neurological adverse drug reactions (ADR) caused by montelukast were included. Such information as the gender and age of patients, dosage, the time adverse drug reactions in the nervous system occurred and clinical manifestations was classified and summarized.
RESULTS A total of 112 patients aged 1 to 86 were collected. ADR mostly occurred in children under 14 years old. The time of intervals ranged from 30 minutes after medication to 2.5 years, and most of them occurred within one week of medication. The main symptoms of ADR were nightmares, sleep disorders, aggressiveness and anxiety.
CONCLUSION Neurologic and mental ADR caused by montelukast are more common in children, and physicians should weigh the potential risks and benefits based on the patient's condition while remaining alert to the possible risk of suicide. © 2022 Editorial Offfce of Chinese Journal of Pharmacovigilance. All rights reserved.
Language: zh |