Citation

Li X, Chen X, Zhou Y, Dai L, Cui LB, Yu R, Ai M, Huang Q, Tian Y, Ming M, Kuang L. Brain Sci. 2022; 12(9).

Copyright

(Copyright © 2022, Switzerland Molecular Diversity Preservation International (MDPI) AG)

DOI

10.3390/brainsci12091121

PMID

unavailable

Abstract

Resting-state functional magnetic resonance imaging (rs-fMRI) was used to investigate the effects of electroconvulsive therapy (ECT) causing brain function changes in adolescents who suffered from depression and suicidal ideation (SI). A total of 30 patients (MDDs) and 25 healthy controls (HCs) matched by gender, age, and education level were enrolled. The amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) were used to compare differences between HCs and MDDs at baseline, and differences in ALFF and ReHo pre/post ECT in MDDs. Pearson correlation analysis was used to evaluate the relationship between altered brain function and clinical symptoms. At baseline, MDDs showed decreased ALFF in the left inferior temporal gyrus and right amygdala, decreased ReHo in left inferior temporal gyrus, and increased ReHo in the right inferior frontal gyrus, opercular part and left middle occipital gyrus. After ECT, MDDs showed increased ALFF in the right middle occipital gyrus, decreased ALFF in left temporal pole, left inferior frontal gyrus, opercular part, and right frontal middle gyrus, increased ReHo in the right middle occipital gyrus, and left inferior temporal gyrus. Pearson correlation found HAMD scores at baseline were negatively correlated with ALFF in the left inferior temporal gyrus, and HAMD and BSSI scores after ECT were negatively correlated with ALFF in the right middle occipital gyrus. The abnormal activities of amygdala, inferior temporal gyrus and middle occipital gyrus might be related to depressive and suicidal symptoms in adolescents. © 2022 by the authors.

Language: en

Keywords

adolescent; human; female; male; suicidal ideation; depression; prevalence; burnout; anxiety; functional magnetic resonance imaging; prefrontal cortex; suicide attempt; major depression; suicide ideation; hippocampus; neuroimaging; controlled study; antidepressant agent; anxiolytic agent; neuroleptic agent; clinical article; fluoxetine; sertraline; venlafaxine; quetiapine; nuclear magnetic resonance imaging; electroconvulsive therapy; caregiver; head movement; olanzapine; risperidone; escitalopram; propranolol; correlation analysis; brain function; brain region; suxamethonium; propofol; cerebrospinal fluid analysis; educational status; aripiprazole; Article; clinical assessment; trihexyphenidyl; muscle relaxation; gray matter; infrared spectroscopy; MDD; tandospirone; clinical outcome; Hamilton Depression Rating Scale; amygdala; superior frontal gyrus; echo planar imaging; middle occipital gyrus; amplitude of low-frequency fluctuation; inferior frontal gyrus; ALFF; regional homogeneity; inferior temporal gyrus; ReHo; T1 weighted imaging