Citation

Aykaç, Çelik FND, Yilmaz R, Bayram E, Akbostancı MC, Karan O. Turk Noroloji Dergisi 2022; 28(1): 10-13.

Copyright

(Copyright © 2022)

DOI

10.4274/tnd.2021.15689

PMID

unavailable

Abstract

OBJECTIVE: Akathisia is frequently seen as a drug side-effect. In Parkinson's disease (PD), it is relatively understudied. Moreover, few studies investigating akathisia differ concerning the assessment methods and prevalence rates, indicating a need for an objective approach. Our aim is to determine the prevalence of akathisia with an objective assessment tool and to investigate its relationship with neuropsychiatric symptoms and suicidal tendency.

MATERIALS AND METHODS: One-hundred-one patients with PD and 75 age-and sex-matched control subjects were enrolled. Patients and controls were compared in terms of the presence of akathisia. Further, patients with and without akathisia were compared with regard to disease stage, severity, peak dose dyskinesia, suicide probability, presence of anxiety, and depression using validated tools.

RESULTS: Akathisia was more frequent in patients with PD than in controls (6.9 vs. 0% p=0.02). Patients with akathisia scored worse in unified PD rating scale-part II (experiences of daily living) and reported anxiety and dyskinesia more frequently. The probability of suicidality was similar in patients with or without akathisia.

CONCLUSION: Our findings reveal that akathisia is more frequent in patients with PD than controls, and is associated with anxiety. © The Authors.

Language: en

Keywords

adult; human; suicide; female; male; aged; suicidality; depression; anxiety; suicidal behavior; disease severity; major clinical study; controlled study; cross-sectional study; akathisia; levodopa; Parkinson disease; probability; disease duration; dyskinesia; Article; Mini Mental State Examination; Unified Parkinson Disease Rating Scale; Hamilton Depression Rating Scale; Hoehn and Yahr scale; Parkinson’s disease