Citation

Liu M, Huang Y, Li X, Liu Y, Yu R, Long Y, Lv F, Zhou X. Front. Psychiatry 2022; 13.

Copyright

(Copyright © 2022, Frontiers Media)

DOI

10.3389/fpsyt.2022.1007144

PMID

unavailable

Abstract

BACKGROUND: The neurobiological basis of suicidal behaviors among female adolescents with major depressive disorder (MDD) remains largely unclear.

MATERIALS AND METHODS: Fifty-eight drug-naïve, first-episode female adolescent MDD [including 31 patients with suicidal attempt (SA group) and 27 patients without SA (non-SA group)], and 36 matched healthy controls (HCs) participated in the present study. Resting-state functional magnetic resonance imaging (MRI) was performed on each subject. The metrics of the amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) were compared among the three groups. Then seed-based functional connectivity (FC) was conducted based on the ALFF/fALFF and ReHo results, which were then correlated to clinical variables.

RESULTS: Compared with the non-SA group, the SA group exhibited increased fALFF in the bilateral insula and right precentral gyrus, and enhanced ReHo in the left superior temporal gyrus, left middle cingulate cortex, right insula, and right precentral gyrus. Relative to the HCs, the SA group demonstrated additionally reduced fALFF and ReHo in the left middle frontal gyrus. Moreover, the SA group showed increased FC between the right precentral gyrus and the left middle frontal gyrus and left insula, and between the right insula and anterior/middle cingulate cortex compared to the non-SA and HC groups. In addition, the fALFF in the left middle frontal gyrus was positively correlated with the 17-item Hamilton Depression Rating Scale scores, and the values in the fALFF/ReHo in the right insula were positively correlated with the duration of MDD within the patient group.

CONCLUSION: These findings highlight the multiple abnormalities of the frontolimbic circuit, which may enhance our understanding of the neurobiological basis underlying female MDD with SA during adolescence. Copyright © 2022 Liu, Huang, Li, Liu, Yu, Long, Lv and Zhou.

Language: en

Keywords

adolescent; human; female; functional magnetic resonance imaging; major depressive disorder; suicide attempt; major depression; suicidal attempt; controlled study; clinical article; brain region; disease duration; women's health; Article; cingulate gyrus; insula; nerve cell network; Hamilton Depression Rating Scale; superior temporal gyrus; primary motor cortex; adolescent depression; functional connectivity; middle frontal gyrus; amplitude of low-frequency fluctuation; fractional amplitude of low-frequency fluctuation; frontolimbic circuit; functional MRI; regional homogeneity