Citation

Liu F, Huang L, Zhu R, Peng C, Deng X. Ann. Med. Psychol. (Paris) 2021; 179(4): 329-333.

Copyright

(Copyright © 2021, Societe Medico-Psychologique, Publisher Elsevier Publishing)

DOI

10.1016/j.amp.2020.12.022

PMID

unavailable

Abstract

BACKGROUND: Thyroid dysfunction was correlated with suicidality, but the relationship of thyroid dysfunction and suicide attempts in patients with major depression disorder (MDD) was unclear.

OBJECTIVE: The present study aims to investigate the prevalence and clinical correlations, particularly thyroid dysfunction associated factors of suicide attempts in Chinese MDD patients. We recruited a total of 1589 MDD patients with MDD. Their social-demographic and clinical data gather with lipid, fasting plasma glucose and thyroid function parameters were obtained. The positive subscale of the Positive and Negative Syndrome Scale (PANSS), Hamilton Anxiety Rating Scale (HAMA) and 17-item Hamilton Depression Rating Scale (HAMD) were rated for all participants.

RESULTS: The results indicated that comparison with non-suicide attempters, the suicide attempters had longer duration of illness, greater scores on HAMD, HAMA and PANSS psychotic symptoms and higher serum levels in thyroid stimulating hormone (TSH), anti-thyroglobulin (ATG) and thyroid peroxidases antibody (ATPO) (all P < 0.001). A binary logistic regression analysis indicated that suicide attempts were associated with severe thyroid dysfunction with an adjusted odds ratio (OR) of 2.35, higher HAMA scores, TSH and ATPO with an adjusted OR of 1.28, 1.19 and 1.00, respectively.

CONCLUSION: Our results found TSH, ATG and ATPO might be potential biomarkers of suicide risk in MDD, indicating the significance of routine evaluation of thyroid function to better prevent suicide, and active treatment for thyroid dysfunction for intervention of suicide among MDD patients. © 2020

Language: en

Keywords

adult; human; Depression; female; male; Prevalence; Risk factor; Suicide attempt; suicide attempt; major depression; major clinical study; controlled study; thyrotropin; thyrotropin blood level; cross-sectional study; glucose blood level; Thyroid; Chinese; thyroid disease; Article; Positive and Negative Syndrome Scale; Hamilton Anxiety Scale; thyroid function; antibody blood level; thyroid peroxidase antibody; Hamilton Depression Rating Scale; Disease of the endocrine system; thyroglobulin antibody