Citation

Zhou J, Xu XY, Zhang CQ, Luo H, Zhang L, Jiang Y, Hu YQ. Chinese Pharmacological Bulletin 2021; 37(12): 1648-1653.

Copyright

(Copyright © 2021)

DOI

10.3969/j.issn.1001-1978.2021.12.005

PMID

unavailable

Abstract

Major depressive disorder (MDD) has a high disability rate and a high risk of suicide. Due to the limited efficacy of traditional antidepressants, researchers have actively developed animal models with different mechanisms to meet the clinical needs. The principle and preparation methods, phenotypic characteristics, model validity (simulating clinical MDD) and their advantages and disadvantages of different models have been reviewed in this article. It is helpful for researchers to explore the pathogenesis of MDD and to select appropriate animal models in the development of new anti-MDD drugs. © 2021 Publication Centre of Anhui Medical University. All rights reserved.

Language: zh

Keywords

stress; major depressive disorder; animal model; antidepressant drugs; model validity; phenotypic characteristics; rodents